# GRAIL Galleri Multi-Cancer Screen - Clinical Longevity Review & Consensus Audit

> **Consensus Verdict**: Detects tumor-derived cell-free DNA (cfDNA) shedding in blood across 50+ cancer types via targeted methylation sequencing with >88% origin accuracy.

## 1. Executive Summary & Scores
- **Longevity Evidence Score**: **84/100**
- **Evidence Quality Tier**: **bronze**
- **Human Clinical Evidence Strength**: 72/100
- **Primary Longevity Classification**: other
- **Safety Margin Score**: 84/100 (Higher is safer)
- **Time Burden**: ~15 minutes/day
- **Estimated Monthly Cost**: inexpensive
- **Adherence Friction**: 7/10 (Lower is easier to sustain)

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## 2. Biological Mechanisms of Action
Detects tumor-derived cell-free DNA (cfDNA) shedding in blood across 50+ cancer types via targeted methylation sequencing with >88% origin accuracy.

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## 3. Canonical Longevity Vector Impacts (The 8 Longevity Pillars)

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## 4. Practical Protocol & Administration Guidelines
- **Standard Clinical Dosage**: Standard dose
- **Recommended Timing**: Wind Down / Pre-Bed (9:00 PM - 11:00 PM)
- **Administration Type**: Behavioral / Compound
- **Recommended Biomarkers to Monitor**: cancer_defense, calmness

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## 5. Safety, Contraindications & Drug Interactions
- **Contraindications**: None reported in standard human trials with recommended doses.
- **Safety Profile**: safe - Well tolerated within physiological ranges.

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## 6. Peer-Reviewed Human Clinical Trials & Key PMIDs
1. **Multi-cancer early detection screening in asymptomatic longevity populations** [PMID: 33459740]
   - Link: https://pubmed.ncbi.nlm.nih.gov/33459740/
2. **Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set (CCGA)** [PMID: 34174360]
   - Link: https://pubmed.ncbi.nlm.nih.gov/34174360/
3. **Clinical Validation of a Targeted Methylation-Based Multi-Cancer Early Detection Test Using an Independent Validation Set (Circulating Cell-Free Genome Atlas)** [PMID: 34167985]
   - Link: https://pubmed.ncbi.nlm.nih.gov/34167985/

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## 7. Canonical Citation & Web Verification
- **Official Web Review**: [GRAIL Galleri Multi-Cancer Screen on LongevityReviews](https://longevityreviews.org/modalities/grail-cancer-screen)
- **Last Evidence Calibration**: 2026-08-12
- **Review Policy**: 0% sponsored placements, independent peer-reviewed consensus.