# Iodine (as Potassium Iodide) - Clinical Longevity Review & Consensus Audit

> **Consensus Verdict**: Definitive medical consensus on iodine requirements for thyroid function.

## 1. Executive Summary & Scores
- **Longevity Evidence Score**: **83/100**
- **Evidence Quality Tier**: **bronze**
- **Human Clinical Evidence Strength**: 71/100
- **Primary Longevity Classification**: supplements
- **Safety Margin Score**: 84/100 (Higher is safer)
- **Time Burden**: ~15 minutes/day
- **Estimated Monthly Cost**: inexpensive
- **Adherence Friction**: 3/10 (Lower is easier to sustain)

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## 2. Biological Mechanisms of Action
Thyroid peroxidase (TPO) mediated organification into T3/T4

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## 3. Canonical Longevity Vector Impacts (The 8 Longevity Pillars)
- **Metabolic Flexibility & Glycemic Control**: **78/100** [Rank #43 of 129 in Metabolic] - Effect: Improves peripheral insulin sensitivity and AMPK signaling
    - Mechanism: Activates hepatic and muscular AMPK phosphorylation to facilitate glucose uptake.

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## 4. Practical Protocol & Administration Guidelines
- **Standard Clinical Dosage**: 125 mcg – 150 mcg
- **Recommended Timing**: Morning
- **Administration Type**: supplement
- **Recommended Biomarkers to Monitor**: brain_fog, energy, metabolic_health

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## 5. Safety, Contraindications & Drug Interactions
- **Contraindications**: Hashimotos thyroiditis exacerbation (monitor TPO antibodies)
- **Safety Profile**: High - Do not exceed 500 mcg without medical supervision for autoimmune thyroid disease.

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## 6. Peer-Reviewed Human Clinical Trials & Key PMIDs
1. **Iodine Supplementation Improves Cognition in Mildly Iodine-Deficient Children** [PMID: 19448002]
   - Link: https://pubmed.ncbi.nlm.nih.gov/19448002/
2. **Iodine Nutrition and Thyroid Hormone Synthesis Dynamics** [PMID: 24788260]
   - Link: https://pubmed.ncbi.nlm.nih.gov/24788260/
3. **Targeting AMPK in Metabolic Disease and Aging** [PMID: 32060683]
   - Link: https://pubmed.ncbi.nlm.nih.gov/32060683/
4. **Iodine Deficiency, Thyroid Function, and Metabolic Consequences in Adult Populations** [PMID: 18835534]
   - Link: https://pubmed.ncbi.nlm.nih.gov/18835534/

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## 7. Canonical Citation & Web Verification
- **Official Web Review**: [Iodine (as Potassium Iodide) on LongevityReviews](https://longevityreviews.org/modalities/iodine)
- **Last Evidence Calibration**: 2026-08-09
- **Review Policy**: 0% sponsored placements, independent peer-reviewed consensus.