# L-Lysine - Clinical Longevity Review & Consensus Audit

> **Consensus Verdict**: Established essential amino acid role in protein synthesis, intestinal calcium absorption, and viral suppression.

## 1. Executive Summary & Scores
- **Longevity Evidence Score**: **82/100**
- **Evidence Quality Tier**: **bronze**
- **Human Clinical Evidence Strength**: 71/100
- **Primary Longevity Classification**: supplements
- **Safety Margin Score**: 84/100 (Higher is safer)
- **Time Burden**: ~15 minutes/day
- **Estimated Monthly Cost**: inexpensive
- **Adherence Friction**: 3/10 (Lower is easier to sustain)

---

## 2. Biological Mechanisms of Action
Lysyl oxidase substrate for covalent collagen triple-helix assembly

---

## 3. Canonical Longevity Vector Impacts (The 8 Longevity Pillars)

---

## 4. Practical Protocol & Administration Guidelines
- **Standard Clinical Dosage**: 1,000 mg – 2,000 mg
- **Recommended Timing**: Dinner
- **Administration Type**: supplement
- **Recommended Biomarkers to Monitor**: immune_resilience, skin_clarity

---

## 5. Safety, Contraindications & Drug Interactions
- **Contraindications**: Renal failure without amino acid restriction monitoring
- **Safety Profile**: Very High - Non-toxic essential amino acid.

---

## 6. Peer-Reviewed Human Clinical Trials & Key PMIDs
1. **L-Lysine Supplementation for Herpes Simplex Virus Suppression** [PMID: 3115841]
   - Link: https://pubmed.ncbi.nlm.nih.gov/3115841/
2. **Lysine Residues in Collagen Cross-Linking and Structural Matrix Integrity** [PMID: 22467382]
   - Link: https://pubmed.ncbi.nlm.nih.gov/22467382/
3. **Effect of Tyrosine Supplementation on Clinical and Healthy Populations Under Stress or Cognitive Demands: A Systematic Review** [PMID: 26431831]
   - Link: https://pubmed.ncbi.nlm.nih.gov/26431831/

---

## 7. Canonical Citation & Web Verification
- **Official Web Review**: [L-Lysine on LongevityReviews](https://longevityreviews.org/modalities/l-lysine)
- **Last Evidence Calibration**: 2026-08-09
- **Review Policy**: 0% sponsored placements, independent peer-reviewed consensus.