# Low-Dose Aspirin (81mg) - Clinical Longevity Review & Consensus Audit

> **Consensus Verdict**: Decades of secondary prevention cardiovascular trial data.

## 1. Executive Summary & Scores
- **Longevity Evidence Score**: **83/100**
- **Evidence Quality Tier**: **bronze**
- **Human Clinical Evidence Strength**: 73/100
- **Primary Longevity Classification**: supplements
- **Safety Margin Score**: 84/100 (Higher is safer)
- **Time Burden**: ~15 minutes/day
- **Estimated Monthly Cost**: inexpensive
- **Adherence Friction**: 3/10 (Lower is easier to sustain)

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## 2. Biological Mechanisms of Action
Irreversible COX-1 active site acetylation & Thromboxane A2 blockade

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## 3. Canonical Longevity Vector Impacts (The 8 Longevity Pillars)
- **Heart Health & Endothelial Function**: **75/100** [Rank #56 of 133 in Heart] - Effect: Supports arterial compliance and vascular tone
    - Mechanism: Promotes microvascular nitric oxide bioavailability and reduces lipid peroxidation.

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## 4. Practical Protocol & Administration Guidelines
- **Standard Clinical Dosage**: 81 mg (3x per week)
- **Recommended Timing**: Bedtime (3x/week)
- **Administration Type**: supplement
- **Recommended Biomarkers to Monitor**: heart_health, chronic_inflammation

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## 5. Safety, Contraindications & Drug Interactions
- **Contraindications**: Active peptic ulcer disease, Bleeding disorders / Hemophilia
- **Safety Profile**: Moderate - Risk of GI mucosal bleeding; pulsed 3x/week schedule minimizes ulcer risk.

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## 6. Peer-Reviewed Human Clinical Trials & Key PMIDs
1. **Cardiovascular Risk Reduction and Vascular Elasticity** [PMID: 30598199]
   - Link: https://pubmed.ncbi.nlm.nih.gov/30598199/
2. **Aspirin for the Primary and Secondary Prevention of Vascular Events** [PMID: 19482410]
   - Link: https://pubmed.ncbi.nlm.nih.gov/19482410/
3. **Low-Dose Aspirin and Risk of Colorectal Cancer and Systemic Inflammation** [PMID: 22433256]
   - Link: https://pubmed.ncbi.nlm.nih.gov/22433256/
4. **Aspirin for the Prevention of Cardiovascular Disease and Colorectal Cancer: US Preventive Services Task Force Recommendation Statement** [PMID: 35471505]
   - Link: https://pubmed.ncbi.nlm.nih.gov/35471505/

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## 7. Canonical Citation & Web Verification
- **Official Web Review**: [Low-Dose Aspirin (81mg) on LongevityReviews](https://longevityreviews.org/modalities/low-dose-aspirin)
- **Last Evidence Calibration**: 2026-08-09
- **Review Policy**: 0% sponsored placements, independent peer-reviewed consensus.