# Oral Microbiome & Periodontal Pathogen Screen - Clinical Longevity Review & Consensus Audit

> **Consensus Verdict**: Quantitative PCR quantifies high-risk bacterial DNA shedding (P. gingivalis, T. forsythia, T. denticola) that secretes gingipain proteases, degrading vascular tight junctions.

## 1. Executive Summary & Scores
- **Longevity Evidence Score**: **82/100**
- **Evidence Quality Tier**: **bronze**
- **Human Clinical Evidence Strength**: 70/100
- **Primary Longevity Classification**: other
- **Safety Margin Score**: 84/100 (Higher is safer)
- **Time Burden**: ~15 minutes/day
- **Estimated Monthly Cost**: inexpensive
- **Adherence Friction**: 3/10 (Lower is easier to sustain)

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## 2. Biological Mechanisms of Action
Quantitative PCR quantifies high-risk bacterial DNA shedding (P. gingivalis, T. forsythia, T. denticola) that secretes gingipain proteases, degrading vascular tight junctions.

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## 3. Canonical Longevity Vector Impacts (The 8 Longevity Pillars)

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## 4. Practical Protocol & Administration Guidelines
- **Standard Clinical Dosage**: Standard dose
- **Recommended Timing**: Wind Down / Pre-Bed (9:00 PM - 11:00 PM)
- **Administration Type**: Behavioral / Compound
- **Recommended Biomarkers to Monitor**: immune_resilience, heart_health

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## 5. Safety, Contraindications & Drug Interactions
- **Contraindications**: None reported in standard human trials with recommended doses.
- **Safety Profile**: safe - Well tolerated within physiological ranges.

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## 6. Peer-Reviewed Human Clinical Trials & Key PMIDs
1. **Salivary pathogen screening for targeted periodontal antimicrobial therapy** [PMID: 17329696]
   - Link: https://pubmed.ncbi.nlm.nih.gov/17329696/
2. **Periodontitis: from microbial dysbiosis to systemic inflammation and arterial plaque disruption** [PMID: 25421721]
   - Link: https://pubmed.ncbi.nlm.nih.gov/25421721/
3. **Porphyromonas gingivalis in Alzheimer Disease Brains: Infiltration and Gingipain Toxicity** [PMID: 30679808]
   - Link: https://pubmed.ncbi.nlm.nih.gov/30679808/

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## 7. Canonical Citation & Web Verification
- **Official Web Review**: [Oral Microbiome & Periodontal Pathogen Screen on LongevityReviews](https://longevityreviews.org/modalities/oral-microbiome-pathogen-screen)
- **Last Evidence Calibration**: 2026-08-12
- **Review Policy**: 0% sponsored placements, independent peer-reviewed consensus.