Editorial Standards & Independence Guarantee
In an era flooded with affiliate listicles, sponsored influencer claims, and exaggerated rodent studies, LongevityReviews.org exists as a strictly non-commercial, mathematically grounded evidence ledger.
1. Zero Commercial Influence Guarantee
We never accept payment, equity, free products, or consulting fees from supplement brands, biotech startups, or medical clinics to alter or boost consensus scores.
Consensus ratings and rank orders are completely isolated from commercial affiliate networks. We do not earn commissions when you select or purchase an intervention.
All 269 modalities and 59 protocol stacks are evaluated against the identical Oxford CEBM and Cochrane RoB 2 rubric. Zero pay-to-play gating exists.
2. Continuous Literature Ingestion & Evaluation Pipeline
Continuous PubMed NCBI Harvesting
Our ingestion engine indexes newly published peer-reviewed literature from high-impact journals (*Cell, Nature Medicine, The Lancet, JAMA, NEJM*), matching interventions by canonical chemical identifier and MeSH terms.
Quantitative Endpoint & Biomarker Extraction
We extract verified quantitative deltas (percentage change, absolute difference, confidence intervals, and $p$-values) mapped strictly to established clinical biomarkers (ApoB, VO2 Max, FMD, HOMA-IR, DunedinPACE, etc.).
Cochrane Risk of Bias 2 (RoB 2) Algorithmic Auditing
Trials are audited for randomization validity, allocation concealment, double-blinding, selective outcome reporting, and commercial funding bias. Studies funded directly by product manufacturers receive automatic algorithmic risk-of-bias penalties.
Oxford CEBM & GRADE Level Assignment
Evidence certainty is graded according to international GRADE standards: High (A), Moderate (B), Low (C), or Very Low (D), combined with Oxford Centre for Evidence-Based Medicine (CEBM) hierarchy tiers.
3. The Preclinical Quarantine Policy
The single largest driver of scientific misinformation in the longevity field is the careless conflation of rodent or cellular experiments with human outcomes.
Interventions demonstrating lifespan extension solely in rodents (e.g., NIA Interventions Testing Program mice), worms (*C. elegans*), or cell culture cannot receive a Grade A or B human longevity consensus on LongevityReviews.org. They are explicitly quarantined under Preclinical / Translational status until replicated in randomized, controlled human trials with hard clinical biomarkers.
LongevityReviews.org provides open-access scientific synthesis and research indexing. Content published on this platform is for educational, journalistic, and investigative purposes only and does not constitute medical advice, diagnosis, or treatment recommendations. Always consult a qualified healthcare professional before beginning any medical, nutritional, or longevity protocol.